Zo·que (s??k?) n. pl. Zoque also Zo·ques 1. A member of a group of indigenous peoples of Chiapas and adjacent Mexican states. 2. Any of the Mixe-Zoquean languages spoken by these peoples. [Spanish zoque, tzoque, of unknown origin.] American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.