zon·ule (z?n?yo?ol)n. A small zone, as of a ligament.American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.zonule (?z?nju?l) na small zone, band, or area[C19: from New Latin z?nula a little zone] zonular adjCollins English Dictionary ? Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014zon?ule (?zo?n yul) n. a little zone, belt, band, or the like. [1825?35;