Worces·ter·shire sauce (wo?os?t?r-shîr, -sh?r)n. A piquant sauce of vinegar, molasses, anchovies, tamarind concentrate, and other ingredients.[After Worcestershire, a county in west-central England where it was first made.]American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.Worces?tershire sauce` n. a sharp sauce of soy, vinegar, spices, etc., orig. made in Worcester, England. [1680?90] Random House Kernerman Webster’s College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.