chlor·phen·ir·a·mine maleate (klôr?f?n-îr??-m?n?)n. An antihistamine, C20H23ClN2O4, used to relieve the symptoms of upper respiratory allergies or the common cold, such as runny nose and sneezing.[chlor(o)- + phen(yl) + alteration of (p)yr(idine) + amine.]American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.