San An·ge·lo (s?n ?n?j?-l??) A city of west-central Texas south-southwest of Abilene. A notorious frontier town in the 1870s, it grew after the coming of the railroad in 1888.American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.San An?ge?lo (sæn ?æn d???lo?) n. a city in W Texas. 87,340. Random House Kernerman Webster’s College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.