Cho·lu·la (ch?-lo?o?l?, ch?-lo?o?lä) A town of east-central Mexico west of Puebla. Site of an ancient Toltec center and a city sacred to the Aztecs, it was destroyed by Hernando Cortés in 1519.American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.Cholula (Spanish t?o?lula) n (Placename) a town in S Mexico, in Puebla state: ancient ruins, notably a pyramid, 53 m (177 ft) high. Pop: 82 964 (2005)Collins English Dictionary ? Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014Cho?lu?la (t???lu l?) n. a town in S Mexico, SE of Mexico City: ancient Aztec ruins. 20,913. Random House Kernerman Webster’s College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.