hoo·doo (ho?o?do?o)n. pl. hoo·doos 1. a. Magic healing and control, especially in African-based folk medicine in the United States and the Caribbean. Also called conjure.b. A practitioner of hoodoo.2. Voodoo.3. a. Bad luck.b. One that brings bad luck.4. Geology A column of eccentrically shaped rock, produced by differential weathering.tr.v. hoo·dooed, hoo·doo·ing, hoo·doos 1. To practice hoodoo on; affect with a charm or curse.2. To bring bad luck to.[Of West African origin, possibly from voodoo.]hoo?doo·ism n.American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.