Cain (k?n) In the Bible, the eldest son of Adam and Eve, who murdered his brother Abel out of jealousy and was condemned to be a fugitive.American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.cain (ke?n) or kainn (Historical Terms) history (in Scotland and Ireland) payment in kind, usually farm produce paid as rent[C12: from Scottish Gaelic c?in rent, perhaps ultimately from Late Latin can?n tribute (see canon); compare Middle Irish c?in law]Cain (ke?n) n1. (Biography) the first son of Adam and Eve, who killed his brother Abel (Genesis 4:1?16)2. raise Cain a. to cause a commotionb. to react or protest heatedlyCollins English Dictionary ? Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014Cain (ke?n) n. the first son of Adam and Eve, who murdered his brother Abel. Gen. 4. Idioms: raise Cain, to behave boisterously or violently; make a disturbance. Cain?it?ic, adj. Cain (ke?n) James M., 1892?1977, U.S. novelist. Random House Kernerman Webster’s College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.