strep throatn. An infection of the throat caused by streptococcal bacteria and marked by fever, pain, and enlargement of lymph nodes.American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.strep? throat? n. an acute sore throat caused by hemolytic streptococci. [1925?30] Random House Kernerman Webster’s College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.strep throat (str?p) Infection of the throat caused by streptococcus bacteria. Symptoms include fever, redness of the throat, and inflammation of the tonsils.The American Heritage® Student Science Dictionary, Second Edition. Copyright © 2014 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.