py·o·gen·ic (p???-j?n??k)adj. Producing pus.American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.py?o?gen?ic (?pa? ??d??n ?k) adj. 1. producing or generating pus. 2. attended with or pertaining to the formation of pus. [1830?40] Random House Kernerman Webster’s College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.