-phreniasuff. Mental disorder: schizophrenia.[From Greek phr?n, mind; see gwhren- in Indo-European roots.]American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.-phrenia a combining form used in the names of mental conditions or states, as specified by the preceding element: schizophrenia. [