O’o·dham (ô??-däm, ô?däm)n. pl. O’odham or O’o·dhams 1. A member of a Native American people inhabiting desert regions of southern Arizona and northern Sonora, Mexico.2. The Uto-Aztecan language of this people, closely related to Pima. In both senses also called Papago, Tohono O’odham.American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.