no-lose (n??lo?oz?)adj. Slang Certain to end happily or successfully: “It is a no-lose situation: The hungry get the food, the donors get a tax deduction” (Los Angeles Times).American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.