Is.abbr.1. Bible Isaiah2. island3. isleAmerican Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.Is. abbreviation for 1. (Bible) Bible Isaiah. Also: Isa 2. (Physical Geography) Island(s) or Isle(s) Collins English Dictionary ? Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014