Home Office n (Government, Politics & Diplomacy) government Brit the national department responsible for the maintenance of law and order, immigration control, and all other domestic affairs not specifically assigned to another department Collins English Dictionary ? Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014home? of?fice n. 1. the main office of a company. 2. (caps.) the governmental department in Great Britain dealing with domestic matters, as elections and the control of police. 3. a work or office space set up in a person’s home and used exclusively for business on a regular basis. [1860?65] Random House Kernerman Webster’s College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.