F layern.1. The highest region of the ionosphere, extending at night from about 190 to 400 kilometers (120 to 250 miles) and during the day from about 145 to 400 kilometers (90 to 250 miles) above the earth. Also called F region.2. Either of two layers, designated F1 and F2, into which this region is divided during the day, extending respectively from about 145 to 240 kilometers (90 to 150 miles) and from about 190 to 400 kilometers (120 to 250 miles) above the earth.American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.F layer n. the highest radio-reflective region of the ionosphere, at an altitude of ab. 80 mi. (130 km). [1925?30] Random House Kernerman Webster’s College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.