Cuz·co (ko?oz?k?, ko?os?-) also Cus·co (ko?os?-) A city of southern Peru in the Andes east-southeast of Lima. Founded according to legend by Manco Capac around the 12th century, it became the center of the vast Inca Empire and was rebuilt by the Spanish after its plunder by Francisco Pizarro in 1533.American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.Cuzco (Spanish ?kusko) or Cuscon (Placename) a city in S central Peru: former capital of the Inca Empire, with extensive Inca remains; university (1692). Pop: 307 000 (2005 est)Collins English Dictionary ? Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014Cuz?co or Cus?co (?kus ko?) n. a city in S Peru: Inca ruins. 255,568. Random House Kernerman Webster’s College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.