co·me·di·enne (k?-m??d?-?n?)n. A woman professional entertainer who tells jokes or performs various other comic acts.[French comédienne, feminine of comédien, comedian; see comedian.]American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.comedienne (k??mi?d???n) n (Theatre) a female comedian. Gender-neutral form: comic Collins English Dictionary ? Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014co?me?di?enne (k??mi di??n, -?me?-) n. a female comic entertainer or actress. [1855?60;