-coel or -coele or -celesuff. Chamber; cavity: blastocoel.[New Latin -coela, from Greek koilos, hollow; see keu?- in Indo-European roots.]American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.