zy·mog·ra·phy (z?-m?g?r?-f?)n. An electrophoretic technique used to detect the identity and activity of a protease in a sample or tissue, in which the protease is allowed to react with a protein substrate, as in a gel, and the products of the reaction are identified with stains or by other means.[(en)zyme + -graphy.]American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.