hy·dro·co·done (h??dr?-k??d?n)n. A narcotic drug derived from codeine, C18H21NO3, used in its bitartrate form as an analgesic and antitussive.[(di)hydrocod(ein)one.]American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.hydrocodone (?ha?dr??k??d??n) na semi-synthetic opioid drug derived from codeine and thebaineCollins English Dictionary ? Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014