zol·mi·trip·tan (z?l?m?-tr?p?tn)n. A drug that acts as a serotonin receptor agonist and is used to treat migraine headaches.[(a)zol(e) + (a)mi(no) + -triptan, triptan suffix; see triptan.]American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.