ESA abbreviation for 1. (Environmental Science) Environmentally Sensitive Area: an area that contains a natural feature, such as the habitat of a rare species, and which is protected by government regulations 2. (Astronautics) European Space Agency Collins English Dictionary ? Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014ESA European Space Agency. Random House Kernerman Webster’s College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.