Cuy·a·ho·ga River (k???-h??g?, k?-h??-) A river, about 160 km (100 mi) long, of northeast Ohio flowing southwest then north to enter Lake Erie at Cleveland.American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.