xen·o·pus (z?n??-p?s)n. Any of various aquatic, tongueless, clawed frogs of the genus Xenopus of southern Africa, certain species of which, especially the African clawed frog, are widely used for biological research.[New Latin Xenop?s, genus name : xeno- + Greek pous, foot; see octopus.]American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.xenopus (?z?n?p?s) n (Animals) an African clawed frog of the genus Xenopus having no tongue Collins English Dictionary ? Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014