Frank·furt also Frank·furt am Main (fr?nk?f?rt äm m?n?, frängk?fo?ort?) A city of west-central Germany on the Main River. Founded in the first century ad by the Romans, it was the virtual capital of Germany from 1816 to 1866. It is now an industrial, commercial, and financial center.American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.Frankfurt (German ?fra?kf?rt (am ?main)) or Frankfurt am Mainn (Placename) a city in central Germany, in Hesse on the Main River: a Roman settlement in the 1st century; a free imperial city (1372?1806); seat of the federal assembly (1815?66); university (1914); trade fairs since the 13th century. Pop: 643 432 (2003 est)Frankfurt (German ?fra?kf?rt (an der ?o?d?r)) or Frankfurt an der Odern (Placename) a city in E Germany on the Polish border: member of the Hanseatic League (1368?1450). Pop: 67 014 (2003 est)Collins English Dictionary ? Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014Frank?furt (?fræ?k f?rt, ?fr??k f??rt) n. 1. Also called Frank?furt am Main (?fr??k f?rt ?m ?ma?n) a city in W Germany, on the Main River. 652,412. 2. Also called Frank?furt an der O?der (?fr??k f?rt ?n d?r ?o? d?r) a city in NE Germany, on the Oder River. 85,158. Random House Kernerman Webster’s College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.