congenital adrenal hyperplasian. Any of a group of genetic disorders characterized by an enzyme deficiency that leads to insufficient production of cortisol and often aldosterone by the adrenal glands, typically resulting in abnormally high androgen secretion, masculinization of the female genitourinary system, high blood pressure, and, in the most severe cases, uncontrolled blood sodium depletion.American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.