di·sul·fi·ram (d?-s?l?f?-r?m?)n. A drug used in the treatment of alcoholism that interferes with the metabolic degradation of alcohol, producing an unpleasant reaction when even a small quantity of alcohol is consumed.[disulfi(de) + (thiu)ram, one of its constituents (thi(o)- + ur(ea) + am(ide)).]American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.disulfiram (?da?s?l?f??r?m) n (Pharmacology) a drug used in the treatment of alcoholism that acts by inducing nausea and other unpleasant effects following ingestion of alcohol[C20: from tetraethylthiuram disulfide]Collins English Dictionary ? Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014