A·gri·gen·to (ä?gr?-j?n?t?, ?g?r?-) A city of southwest Sicily, Italy, overlooking the Mediterranean Sea. It was founded c. 580 bc by Greek colonists.American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.Agrigento (Italian a?ri?d??nto) n (Placename) a town in Italy, in SW Sicily: site of six Greek temples. Pop: 54 619 (2001). Former name (until 1927): Girgenti Collins English Dictionary ? Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014A?gri?gen?to (?? gri?d??n t?) n. a city in S Italy. 51,931. Random House Kernerman Webster’s College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.